Hodges, H. C. et al. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Both the substitutions introduced in the C2S and R111H mutants altered the presentation of the loop, harbouring Asp123 in the common "jelly-roll" fold.
However, the role of the Toll pathway as a antiviral response remains uncertain because previous studies have shown that Toll pathway genes are not up-regulated by DCV infection [11], and not all Toll pathway mutants alter the flies' susceptibility to DXV [13].
Moreover, the application of salicylic acid to wrky54 mutants altered the expression patterns of AtWRKY38 and AtWRKY70 genes [ 22].
None of these mutants altered the interaction of p85α with p110α, consistent with C-terminus but not N-terminus of p85α contributing to p110α binding.
Although their expression does not change the total levels of peripherin (Fig. 7), CMT2B-causative RAB7A mutants alter the peripherin soluble/insoluble ratio (Fig. 8), suggesting that the process of peripherin filament assembly is at least in part compromised.
To assess whether differences in the total OMC composition of ppk mutants alter the invasion of INT-407 cells by the C. jejuni WT strain, INT-407 cells were exposed to total OMC extracts from WT, Δppk1, or Δppk2 prior to challenge with C. jejuni WT.
Although ZLD mutants alter the expression of a large number of cellular blastoderm genes (Liang et al., 2008), and affect transcription factor binding in the cellular blastoderm (Yanez-Cuna et al., 2012; Foo et al., 2014; Xu et al., 2014), little is known about its molecular function or when its activity is required.
The authors suggested that the S267E mutant altered the charge of the Fc, potentially increasing ionic interactions with the C1q subunit B. Among the four human IgG subclasses, IgG3 has the most potent CDC activity (Tao et al., 1993).
