Sentence examples for mutant zebrafish lines from inspiring English sources

Several transgenic or mutant zebrafish lines were generated to model neurodegeneration in fish [ 105– 108].

In this study, we generated rps19 mutant zebrafish lines using TALENs.

We selected four mutant zebrafish lines from the Zebrafish Mutation Project (ZMP) to test the differential expression transcript counting technique (DeTCT) pipeline.

Importantly, both apoc2 mutant zebrafish lines showed dramatically decreased apoc2 mRNA expression and developed hypertriglyceridemia, validating the Apoc2 loss-of-function model.

The following wild-type, transgenic, and mutant zebrafish lines were used: AB, TL, golden (Lamason et al., 2005), casper (White et al., 2008), Tg nkx2.2a: mEGFP) (Kirby et al., 2006; Ng et al., 2005), Tg(sox10 7.2):mRFP) (Kirby et al., 2006), Tg mbp:EGFP), and Tg mbp:EGFP-CAAX) (Almeida et al., 2011).

In addition, random mutagenesis screens [52,53] have yielded numerous mutant zebrafish lines in which the mutated gene is implicated in a human disease, e.g. muscular dystrophy [54 57], and it is hoped that the continuing screening of mutagenized libraries (e.g. TILLING Targeting Induced Local Lesions in Genomes) will yield mutations in specific genes of relevance to neurodegenerative disorders.

More recently, Da Costa created a new model of zebrafish, the T70I mutant (mutant zebrafish line).

The telomerase mutant zebrafish line used in this study was obtained from the Sanger Institute (hu3430 line).

In order to study this disease further, the vhl mutant zebrafish line was created.

A T70I mutant zebrafish line was characterised using oxidative stress assays, neuromuscular junction (NMJ) analysis and motor function studies.

Here we describe a mutant zebrafish line created by TALEN genome editing carrying a 23 bp deletion in gba1 (gba1 c.1276_1298del), the zebrafish orthologue of human GBA1.