Thus, both single mutants would seem to retain some form of feedback regulation on telomerase action, albeit with an alteration in the TG tract length set point at equilibrium.
Since the VTC1 locus has also been characterized by cyt1 and emb101 mutants, it would seem that the mutant alleles might have some disadvantage in being propagated and a 'residual heterozygosity' might persist by some mechanism.
It has been suggested that maternally supplied Sec13 mRNA and/or protein may also have been the reason for ongoing secretion such as laminin until 5 dpf in Sec13 mutant zebrafish; however, 5 days would seem a rather long half-life for either.
In addition, it would seem that showing the control of a mutant with abrogation of the RNA binding could be useful in the stress granule assays.
This would seem to exclude the possibility that the tumours differentially possessed mutant aromatase which was resistant to the inhibitor (although such phenotypes have been constructed experimentally (Kadohama et al, 1992).
So, as a person who thinks seriously about silly topics, he would seem like an ideal candidate to field this question: What was it about "Teenage Mutant Ninja Turtles" back in the 1980s that made boys go gaga?
Which would seem a pittance.
