Sentence examples for mutant which causes from inspiring English sources

We compared the leaves from the dxr mutant which causes a defect in photosynthesis and exhibits an albino phenotype, with leaves of wild type controls.

It is striking that the S52R mutant, which causes moderately severe FENIB, showed characteristics that are intermediate between wild-type and G392E neuroserpin.

SM migration is affected in egl-15(n484) mutant, which causes posteriorly displaced vulval muscles descended from an SM that stops prematurely during the migration (Goodman et al., 2003).

This is in agreement with the notion that FMRP dimerization is abolished in a I304N mutant, which causes structural and functional destabilization of the KH2 fold [ 3, 23, 25, 47, 48].

Similarly, a T-DNA insertion Leptosphaeria maculans mutant, which causes Phoma stem canker disease on Brassica crops, demonstrated an increase in the frequency of penetration of the plant Arabidopsis thaliana but did not confer an overall higher level of disease (Elliott, Harjono and Howlett 2008).

DOI: http://dx.doi.org/10.7554/eLife.06056.013 To test whether spindle rotation is involved with the him-8 segregation bias, we utilized mei-2 ct98), mei-2 ct98loss of function katanin mutant, which causes a failure of meiotic spartialrotation but stilossllofs polar body functionn and production of viable progeny (McNally et al., 2006).

Also, trafficking via this pathway is reduced by the TC10 mutants with the GDP-bound mutation, which causes AMPA receptors to pile up in the endosomes, and the GTP-bound mutation, which causes AMPA receptors to exit the endosomes but pile up in transport vesicles prior to fusion with the plasma membrane.

The mutations consisted mainly of single-base deletions (5 mutants), which caused inactivation of the gene by frameshifts.

Glycogen degradation was absent in dmc1, ndt80, and smk1 mutants, which caused previously unobserved accumulation of up to 70% glycogen (on dry mass basis, Figure  4i).

We took advantage of these mutants to directly test the requirement for mTORC1 in sequestering TFEB to the lysosome and we asked whether the RagsDN mutants, which cause loss of mTORC1 from the lysosomal surface (Sancak et al, 2010), were able to suppress Torin 1-induced lysosomal accumulation of TFEB as well as TFEB-mTORC1 binding.

One alternate mechanism could act via protection from DNA damage and genome instability in stationary phase; consistent with this idea, rapamycin has recently been shown to repress the phenotypes of cut1 and cut2 chromosome segregation mutants, which cause DNA damage (Ikai et al., 2011).