Sentence examples for mutant when targeted from inspiring English sources

This enzymatically dead mutant, when targeted to the IMS, acting like a dominant negative mutant, had similar effects on the in organello mtRNA synthesis and degradation as those of RNASET2 knockdown (Fig. 5K and 5L).

Knockout of all three sodB genes in A. tumefaciens results in avirulence, while only the sodBI mutant shows reduced virulence when targeted individually [ 61].

However, folding of some of these mutants is still a problem when targeted to certain organelles or fused to other proteins.

The screen presented here yielded two novel hits that were extensively validated to be selectively lethal when targeted in KRAS mutant tumor cells relative to cells lacking this mutation.

For example, a nanoparticle carrying a plasmid DNA encoding a dominant-negative mutant form of RAF kinase was reported to exert antiangiogenesis effects when targeted against av β3 integrins (Hood et al, 2002).

When targeted in rodent models of inflammation using either soluble IL-15Rα or modified IL-15 mutant fusion proteins, amelioration of onset and of existing arthritis is observed.

When targeted to pathogenic mtDNA, mtZFN expression achieves phenotypic rescue of a severe mtDNA-mediated dysfunction by shifting heteroplasmy towards wild-type through selective degradation of mutant mtDNA.

When targeted to pathogenic mtDNA harbouring a point mutation or large-scale deletion, mtZFN expression produces a heteroplasmy shift towards wild-type mtDNA through selective degradation of mutant mtDNA.

In contrast, we did not notice patches of mutant tissue in adult G0 flies when targeting ebony or yellow, indicating that mutations in somatic cells after pDCC6 injection are rare, despite efficient targeting in the germline.

Nevertheless, some differences were observed between the wild type and the hrde-1 mutant when endo-siRNA profiles were examined in detail along the target sites.

In contrast, injections at 2-cell or 4-cell had no effect on LR patterning, even when TBCB mutant mRNA was targeted to the GRP (via injections in the dorsal left blastomere).