Sentence examples for mutant when overexpressed from inspiring English sources

The mutant, when overexpressed in an ftsA deletion strain, showed no dominant negative effect like the SepF mutants A98V and F124S.

YAP also plays a role in human colorectal cancer progression., The Hippo insensitive YAP mutant, when overexpressed, promotes proliferation of undifferentiated progenitor cells in the intestine.

Two different mutants altering the Walker B motif (required for ATP hydrolysis) gave opposite phenotypes: a Cdc6-E224G mutant was lethal and acted as a dominant negative mutant when overexpressed (Perkins and Diffley, 1998), but a double Cdc6-D223A, E224A mutant was viable suggesting the Cdc6 ATP hydrolysis might not be required for its essential function (Weinreich et al., 1999).

This system is buffered by Lgl (LGL-1 – WormBase), which localises to the posterior cortex like PAR-2, and, although non-essential, can rescue the par-2 mutant phenotype when overexpressed (Beatty et al., 2010; Hoege et al., 2010).

The suppression is achieved through the ubiquitin-dependent degradation of Mitofusin, which itself causes PINK1/parkin mutant-like toxicity when overexpressed.

We mutated these motifs and analyzed the antiapoptotic effect and intracellular localization of these mutants of MANF when overexpressed in cultured sympathetic or sensory neurons.

These biochemical assays indicate that while the PHD mutant can be phosphorylated when overexpressed, modification by ubiquitin is abrogated in the PHD mutant.

As shown in Figure 2A and 2D, none of these K → M mutants induced cell death when overexpressed.

The previously discovered ACD mutant HSPB1R127W showed decreased dimerization when overexpressed in neuroblastoma cells [30].

This was confirmed by western blot analysis of overexpressed Ostm1, which can be detected at similar levels in its processed form when coexpressed with wild-type or mutant ClC-7, but not when overexpressed alone (supplementary material Fig. S4).

Counter to this argument, previously we had analysed the ability of Clr4 to mediate H3K9 methylation when overexpressed in mutant backgrounds that exhibit high levels of transcriptional activity at centromeres.