Sentence examples for mutant when coexpressed from inspiring English sources

The wildtype AKT displays significant increase in the kinase activity as compared to the Y176F mutant when coexpressed with either one of the Ack1 constructs, E346K and caAck (Fig. S5E and F).

Studies showed impaired function and dominant negative activity of N359Y mutant TRα1, with some weakening of dominant negative activity of N359Y mutant α2, particularly when coexpressed with normal TRβ1.

A result unique to this study was the observation that some of the reduced-function CPR mutants regained activity when coexpressed with CYP isoforms in the Sf9 insect cells.

The evidence that the ShcY317F mutant is tyrosyl phosphorylated when coexpressed with TRK-T3 indicates that the oncogene targets residues Tyr239/240 of Shc.

The wild-type reporter showed apparent inhibition while the mutant one did not when coexpressed with miR-218 (Fig. 5B, C).

Further, both these mutants inhibit WT Cx50 when coexpressed [ 23– 25].

Our data show that mutant VAPB and mutant seipin accumulate in different inclusions when coexpressed, indicating that the mechanisms that operate in the formation of VAPB inclusions differ from those underlying the formation of ERPO.

The immunofluorescence data support this conclusion showing that when coexpressed with a mutant that contains only the Histidine Domain and the V-domain, GrpL and Grb2 relocate to cytoplasmic vesicles where they colocalize with the HD-PTP mutant.

The KIAA0319 protein, when coexpressed with these Rab5 mutants, colocalizes with the Q79L mutant in large vesicles, while its internalization is prevented in cells expressing Rab5-S34N; this is a very similar localization pattern as those reported for transferrin in the same conditions and suggests that KIAA0319 follows the same clathrin-mediated endocytic pathway.

Although the Y120A/P121A HCCS double mutant was significantly deficient in heme binding, the single Y120A HCCS mutant purified with WT-levels of heme when coexpressed with the cytochrome c substrate.

In contrast, when coexpressed with deletion mutants lacking the Histidine Domain, the two Grb2 adapters have a dispersed cytosolic and nuclear localization.