Sentence examples for mutant were repaired from inspiring English sources

Progeny of the 3'Δ3 mutant were repaired to wild type (wt) while those from the remaining four mutants were heterogeneous, exhibiting a wt secondary structure.

These results suggest that most of the DSBs that cannot be repaired as crossovers in msh4 mutants are repaired using inter-sister recombination.

Still, many of the extra DSBs observed in dpy-28 single mutants are repaired via a CO intermediate (despite the presence of RTEL-1), which suggests the existence of a counteracting mechanism that promotes CO formation.

Following transfection of the ribozyme construct in AsPC-1 cells, mutant p16 mRNA molecules were repaired and p16 protein synthesis restored.

The kinetics of γ-H2AX foci disappearance (Fig 2B) confirmed that in XRCC4-mutant cells, the DNA lesions were repaired, although with lower efficiency than in wt cells, as the percentage of foci remaining at 24 h was 5 ± 8% in XRCC4 wt cells and 19 ± 7% in XRCC4 m/m.

In one blastomere, only one mutant allele was repaired * Some blastomeres failed to be amplified by PCR.

This suggested that DSBs induced in the osrecql4-2 mutant could be repaired by DNA repair systems, including HR, under normal growth conditions, since HR can proceed slowly without RecQ helicase [ 48].

Evidence that CFTR processing mutants could be repaired by a direct rescue approach is the observation that many second-site suppressors can rescue ΔF508 CFTR and other CFTR processing mutants.

Additionally, only one mutant allele (A−28G−25/G−28G−25) was repaired in 3/28 (10.7%) cells, resulting in heterozygosity (Fig. 2E).

However, homozygous mutant embryos could not be repaired in way because of the lack of WT alleles.

Mismatch repair mutants mlh1 displayed 14.5% survival, suggesting that Mn2+ induces an increased load of mismatches that cannot be repaired.