STAT activation through the add-back mutants is stronger than through CAgp130-YFP harboring all Tyr-residues.
The phenotype of chl4 mutants is stronger than that of scc4 mutantsnts and it is therefore hardly surprising that chl4 is epistatic to scc4 m3.
The constitutive ethylene-response phenotype for the etr1;ers1-3 double mutants is stronger than that observed for any previous receptor mutant combination.
In both cases the phenotypes of double mutants are stronger than the ones of single mutants, suggesting that these genes are not forming a linear pathway in order to control pigmentation.
Given two loci with wild-type alleles A and B at the first and second locus, respectively, he studied the expected fixation time for the double-mutant ab under the assumption that selection against individual mutants is strong (and thus the mutation process is nearly irreversible).
Thus, interaction of these evolved Fcab mutants with FcRn was stronger at pH 6.0, whereas the affinity to Her2 was higher at pH 7.4 (Fig. 3C), clearly demonstrating that the measured pH-dependence of antigen binding cannot be a result of partial unfolding at a certain pH.
We found that the export mutant was a stronger activator of an osmoresponsive reporter than wild-type NFAT5 in isotonic conditions (Figure 10).
As shown in Fig. 5A, the MAMM mutant was a strong stimulus to primary macrophages and the TNF-α, IFN-β, RANTES and IP-10 gene expressions were found to be higher than those induced by the positive H5N1 control (t-test, p<0.05).
The intensity of bands corresponding to mutant was very strong as compared to the wild-type for the 0.1 pmole experiment, while for the 1.0 pmole experiment an opposite banding pattern was observed.
Whereas roots of Col, atnup62, complemented and 35S::AtNUP62-GFP transgenic plants were all affected in the presence of 2,4-D, the effect was stronger in the mutant and in the 35S::AtNUP62-GFP genotypes, whose residual primary root growth on 50 nM 2,4-D was only about 21 and 16%% of that on control medium, compared to about 40%% for the other two genotypes (Fig. 3b).
