This difference in gill bud number between mutants was significant (P=0.0018).
The difference between expected and observed surviving LSPP mutants was significant by chi-squared testing as indicated in Table 1.
Moreover, drug resistance due to the emergence of TKI-resistant mutants is significant in advanced phase CML patients.
The identification of these mutants is significant since, due to functional redundancy and the existence of gene families, the deletion of certain individual genes encoding cell wall-related proteins does not usually lead to observable phenotypes.
For example, the values measured at CEN4 for the same wild-type strain (AM3513) in two independent Ipl1 HA-ChIP experiments vary 4-fold (compare Figures 2C and D), calling into question whether the 2-fold reduction in ChIP signals in the Sgo1 mutants is significant.
Where applicable, p-values were also calculated to determine whether the effect of a certain mutation in two different backgrounds (rather than compared to the parent mutant lacking this mutation) is significant.
As Figure 4A shown, under the non-stressed status, the Crh mRNA expression level in Per1 mutant mice was significant lower than the one in M-WT mice (F = 20.9, p<0.01), by contrast, in Per2 mutant mice the mRNA expression level was significantly increased (F = 14.6, p<0.05).
Again, the growth advantage of mutant A15 was significant compared with the two control cells (Figure 7B).
Quantitative analysis performed on paraffin-embedded sections showed that at five months of age, the loss of photoreceptors in mutant mice was significant, with Guca1a+/COD3 mice retaining 69% of cells in the ONL compared with wild-type littermates (Figure 8d).
A slight decrease in transcript levels was observed for PIN2 in elp mutants, which, however, was significant only for elp2.
