Sentence examples for mutant was prone from inspiring English sources
The misfolded S228P mutant was prone to degrade and aggregate in the cells, which finally formed large light-scattering particles in the cataractous lens in patients.
Here we found that the S228P mutant was prone to aggregate and degrade in both of the human and E. coli cells.
The S228P mutant was prone to form intracellular aggregates for both types of fused proteins, while cells expressing GFP-S228P had a larger portion of cells containing aggregates than cells expressing S228P-GFP (Fig. 1C).
The ΔrelA ΔspoT mutant was prone to autoaggregate and precipitate at 26°C.
In our assay, the R42P mutant was prone to misfold and aggregate, but not enough to affect significantly its ability to recruit to mitochondria.
For genotype D, A1757 mutants were prone to accompany with the T1764/G1766 double mutation [ 20].
In flies, sda mutants are prone to paralysis and seizures after exposure to mechanical and electric shock (Marley and Baines 2011; Pavlidis and Tanouye 1995; Zhang et al. 2002).
Indeed, several studies have shown that Parkin RING domain mutants are prone to misfold (24, 25), possibly reflecting the importance of conserved cysteine residues in Parkin's RING domain to bind Zn2+ and provide structural stability.
Identical levels of IRAK-M mRNA were observed for the R70Q and D19N-A23S mutasts as for WT IRAK-M (Additional file 1: Figure S4A), and since all mutants showed similar protein expression upon transient expression in 293T cells it appears that the R70Q and D19N-A23S mutares are prone to increased protein turnover in a more proficient cell type.
To address whether the lin-7-mediated infection phenotype was confounded by lin-7 mutants being prone to matricidal hatching, we treated an allelic series of three independent lin-7 loss-of-function genetic mutants, lin-7 (e1449), lin-7 (e1443) and lin-7 (n106) (Ferguson and Horvitz, 1985), with cdc-25.1 dsRNA to render them sterile (Evans et al., 2008; Shapira and Tan, 2008).
This mutant protein is prone to aggregation and is thereby cytotoxic for neurons, leading to neuronal loss in the striatum and cortex.
