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The quintuple mutant showed the highest solubility and thermostablity, and the double mutant was most resistant to the denaturants.
Of the tested strains, the category I motC− mutant was most virulent and most heavily growing in murine organs (Figure 5).
The K227Q mutant was most active between pH 8.0 and 9.0.
The V434W mutant was most closely fit with a gamma distribution, N = 2, and a rate constant k = 3.9 ± 0.3 × 10−2, faster than wild-type, but without further data we cannot assign structural correlates for the two steps.
These results suggest that the developmental defect in the fiber SCW and production of thinner fiber cell wall in the im mutant was most likely due to the reduction of cellulose.
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The actin and microtubule defects associated with the rom2 mutant are most visible in the minor population of hyperelongated cells that are formed at high temperature conditions.
The EGFRvIII mutant is most common in primary GBM and is rare in secondary GBM, and in patients with anaplastic ODs, the variant is very rare.
As previously described [ 9], we found that the three mutants have different sensitivities for Gleevec with PDGFRα-D842V being least sensitive to the treatment and the V561D mutant being most sensitive.
The aryl binding pocket of the L384G mutant is most likely slightly larger than that of the L384A mutant,[ 10] and this rationalizes its ability to convert compound 2 f, which carries a large trifluoromethyl group at the meta position.
All of these YFP OASF CFP sensor mutants exhibited a significant reduction of FRET compared with wild type, with the A376K mutant being most pronounced (Supplementary Figure S4B; Figure 3A and C).
However, it has been shown that disruption of β1,3-glucan perturbs invasive growth (Birkaya et al. 2009), and we did not see this in the wsc1 ∆ or skn7 ∆ mutants Thus, the phenotypes of the skn7 ∆ mutant are most like the wsc1 ∆ mutant, suggesting that Skn7p plays a role downstream of Wsc1p in mat formation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com