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By contrast, intracellular replication of the Mma11 eccCb1::tn mutant was drastically reduced as compared with that of the wild-type strain (Fig. 3A).

In contrast, the activity of the D3A-M44L mutant was drastically lower (∼50%) than that of procaspase-3-D3A, indicathat that Met-44 may have an important role in regulating caspase-3 activity regardless of PDT.

The replicative lifespan of the rad2C65Δ mutant was drastically decreased after UV exposure, which is reminiscent of the crucial symptoms of XPG/CS patients such as growth retardation and premature aging that are aggravated after UV exposure.

Consistent with the morphological phenotype, Chl a accumulation in the chlB mutant was drastically lower in short-day conditions than in the WT; Chl a accumulation was reduced to 37.8% (chlB_5 mutant line) and 44.6% (chlB_6 mutant line) in chlB mutant lines compared with WT plants, when they were grown under a 8-h L/16-h D cycle (fig. 3 B and C).

It has repeatedly shown by others that the invasiveness of a ΔsigB mutant is drastically reduced [19], [31], [94], therefore this mutant was not tested here.

All mutants grew comparably well to the WT in the absence of UV irradiation (Fig. 1A), whereas the growth of most rad2CΔ and rad2Δ mutants was drastically delayed following UV irradiation, (Fig. 1B).

Again, at day 5 the average number of liver schizonts formed in the infection initiated with Δp52 mutants is drastically reduced to 1.2 liver schizonts per well.

We found that the swarming behavior of the mutants is drastically different from the parent wild type, with neither SN nor SB being able to swarm.

In dTIEGS14 clones induced early (24 48 hours AEL (after eggs laying)) the survival of the mutant cells (black) was drastically reduced (Fig. 4C).

JA caused severe root growth retardation in wild-type and hy1 mutants, however the effect was drastically reduced in atmyc2 and hy1 atmutantutant plants.

Lundin et al. [ 19] reported that after 15 days of high light (1000 μmol photons m−2 s−1), the psbo1 mutant did not have significantly reduced leaf weight, whereas the leaf weight of psbo2 mutant was reduced drastically.