The heterogeneity of p53 mutants was discovered 25 years ago with the description of the so-called 'structural' mutants, in which the DNA-binding domain is unfolded (e.g. p.R175H), and 'DNA contact' mutants, in which residues interacting directly with DNA are substituted (e.g., p.R273H).
New mutants were discovered independently, displaying excellent enantioselectivity.
Two non-viable mutants were discovered at E16.5 that showed extensive necrosis (data not shown).
Dependable male sterile mutants were discovered and successfully used to change the life cycle of the plants.
In cotton several fiber-related mutants were discovered, from which Ligon lintless-1 (Li 1 ) and Ligon lintless-2 (Li 2 ) were reported to be monogenic and dominant, resulting in an extreme reduction in the length of lint fiber to approximately 6 mm on mature seeds [ 5, 6].
In this study, a male-biased mutant family was discovered from the gynogenetic gibel carp, and a male-specific SCAR marker was identified from the mutant family.
Furthermore, via random mutagenesis, a hVDR mutant, H305F/H397Y, was discovered to bind a novel small molecule, cholecalciferol, a precursor in the 1α,25-dihydroxyvitamin D3 biosynthetic pathway, which does not activate wild-type hVDR.
Here, we report the identification and characterization of a zebrafish sec63 mutant, which was discovered in a screen for mutations that affect the development of myelinated axons.
The other red-flesh mutant 'Hong Anliu' was discovered in China as a bud mutation of 'Anliu' sweet orange; and we found that lycopene in this mutant is 1000-fold higher than that in comparable wild type fruits, and in juice sacs the lycopene accumulation was coincided with increased expression of upstream carotenogenic genes and reduced expression of downstream genes.
