Sentence examples for mutant was detectable from inspiring English sources

Wildtype (WT) UNC93B1 but not the nonfunctional (H412R) mutant was detectable in phagosomes purified from unstimulated RAW264 cells.

By use of the highly sensitive ACRES method, the rtA181T mutant was detectable in 10 of the 123 LAM-resistant patients.

The binding of Trim25 to the pre-let-7a-1@3 mutant was detectable but much weaker compared to wild-type pre-let-7a-1 and the pre-let-7a-1@2 mutant.

Moreover, an altered form of lamin A resembling the HGPS mutant is detectable in normal cells and tissues and may increase with age, while defects in nuclear organization increase with age.

When proline was replaced by alanine or serine, cleavage of the signal sequence did not occur, as the molecular sizes of the mutant receptors did not change and epitopes tagged at N-terminal of the mutants were detectable by immunoblotting (Supplementary Figure S3).

Using full-length DSC2a WT and mutant protein in co-immunoprecipitation experiments, binding to endogenous Cx43 was confirmed for DSC2a WT, whereas no interaction was detectable between the mutant DSC2a and Cx43.

As with site 1 and 2 mutations, we further confirmed that all site 3 mutant proteins were detectable at comparable levels in the cell supernatants.

Together, the 12 cell lines contained seven gene mutants that should be detectable by PAC, as they resulted in the skipping of eight exons from among four tumor suppressor genes (mutations are detailed in Table 1).

However, it was still possible that loss of RB function and activation of MYC may cooperate during tumor development; in particular, MYC/Rb mutant mice have more polyploid hepatocytes compared to MYC mutant mice before tumors are detectable (Figure 5D) and polyploidy has been associated with cancer, including liver cancer [51], [52].

Almost all of wild-type receptor proteins were glycosylated, while not all of mutant proteins were glycosylated because the protein band representing non-glycosylated proteins for the mutant receptor was detectable but that of the wild-type was not demonstrable.

However now, in the presence of PNA, the wild-type-specific peak disappears and the mutant allele was detectable in a 1 : 10 000 dilution (mut/wt).