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It's evolution at its finest: The more opposite the immune systems, the greater the chance of producing bionic children who can withstand those ultra-contagious mutant viruses that are supposedly going to force us all into biohazard containment camps in 2016.
Specifically, replacement R55W in 2C was repeatedly found in several mutant viruses that had regained competence in plaque development.
Therefore, all HSV-2 ICP0− mutant viruses that were IFN-sensitive in cell culture (Fig. 2C) were also avirulent in mice (Fig. 5D).
In contrast, recombinant HSV-2 ICP0− mutant viruses that were IFN-sensitive (Fig. 2, 3) were also avirulent in ICR mice (Fig. 4, 5).
HSV-2 ICP0− mutant viruses that included deletions of ICP0's RING finger domain were avirulent, but did not elicit consistent protection against HSV-2 (Fig. 6B).
Thus, HSV-2 0ΔRING and 0ΔNLS were the only HSV-2 ICP0− mutant viruses that were IFN-sensitive and retained the capacity to replicate with reasonable efficiency in cells that did not provide wild-type ICP0 in trans.
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The mutant virus that included "Spanish Flu -like low-pH-stable NA showed remarkable replication in comparison with the mutant virus that included low-pH-unstable N1 NA.
Ad5/ts369 is an L1-52/55K temperature-sensitive mutant virus that is blocked at an intermediate stage when grown at the non-permissive temperature of 39.5°C [29].
Our data showed that the activation of NF-κB is not restored upon infection with the mutant virus that does not express the ORF47p (ROka47S) compared to infection with the WT virus.
Such occurrence has been described for influenza, for which point mutations are associated with increased virulence (18, 19 ); for example, mutant influenza viruses that arose on chicken farms in Hong Kong in 1997 were transmitted to humans and had fatal consequences (20, 21 ).
Scientists isolated mutant viruses with that property more than four decades ago.
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