Sentence examples for mutant via a from inspiring English sources

The pbTybceABΔloop plasmid was also used to obtain the bceBΔloop strain from the bceAB mutant via a double recombination event.

Moreover, reintroduction of the lasB gene to the P. aeruginosa lasB mutant via a knock-in strategy also successfully restored depilation activity thus confirming the role of LasB as the depilating enzyme.

These include a line of mice that express the A4V mutant (8), mice that express G93A mutant via a Thy1 promoter (10) and mice that express an experimentally truncated SOD1 ending at residue 116 (T116X) (9).

Because of our earlier difficulty in maintaining mutated sites near 5' end of cdc24 by genomic integration, we introduced these mutants via a centromeric plasmid into a strain heterozygous for deletion of CDC24.

In this study, we describe the identification of the causative mutations in three developmental mutants via a strategy involving whole-genome sequencing of pooled DNA from 40 single spore isolates per strain of three mutants and the wild type, in addition to subsequent bioinformatics analyses.

For genes identified originally by mutants via a traditional genetic approach, a candidate gene approach often allowed rapid confirmation of a gene's identity; for predicted genes identified from the genomic sequence by homology, a reverse genetic approach has been taken.

Alongside a profoundly troubling political situation, you see, our notional Costner faces a spectrum of unnatural disasters, from mutant algae via a plague of locusts to possibly toxic weather manipulation.

In a cultured human retinal epithelial cell line, ARPE-19, no splicing defect was observed when the endogenous Hprp3p was replaced by the RP18 mutant protein via a helper-dependent adenoviral vector that simultaneously knocks down the endogenous Hprp3p and expresses a copy of the RP18 mutant PRPF3 [27].

Taken together, these studies strongly suggest that NLK exacerbates the toxicity of the polyQ-expanded mutant AR via a mechanism that depends upon its kinase activity.

Taken together, these data indicate that NLK can influence the activity and toxicity of the mutant AR via a mechanism that is independent, but perhaps parallel to, the AR N/C interaction.

Phenotypic characterization of a yhaM mutant via growth under toxic concentrations of cysteine followed by transcriptional analysis of its response to cysteine showed that yhaM is cysteine-inducible, and its physiological role is associated with resisting the deleterious effects of cysteine in E. coli.