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The most common haplotype is the combination of T786C homozygote wild-type variant with homozygote mutant variants of G5665T (ET-1) and Glu298Asp (eNOS).
The test proteins are mutant variants of the β1 domain of streptococcal protein G that span fairly evenly a thermal stability range from as low as 38 °C to above 100 °C.
To clarify N-terminal processing of the cell-free system in a preparative-scale (> mg protein product per ml), 20 mutant variants of maltose-binding protein (MalE), each having a different penultimate residue in the sequence Met-Xaa-Ile-Glu-, and 20 glutathione S-transferase (GST) variants, having Met-Xaa-Pro-Ile-sequence, were designed and synthesized.
Engineered protein libraries, defined here as a collection of different mutant variants of a single specific protein, are intentionally designed to be rich in molecular diversity and can span ranges from as little as 400 different variants to greater than 1012 members per library.
Similar scenario have been proposed for mutant variants of BRI1 and EFR [72], [74], [75].
IFNγ production was measured in response against all 171 single mutant variants of SFL9.
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One Orthodox cleric in England says some Catholics are embarrassed by the idea that he is a priest and see him as a "funny mutant variant of Catholic".
We further excluded entries mapped to a mutant variant of a kinase, e.g. EGFR(L858R).
In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER).
This mutant variant of EGFR is constitutively activated and expressed in approximately 30% of GBM patients.
pCfvtx was constructed with a stop codon flanked by two multiple cloning sites (MCS1 and MCS2) upstream of Venus [ 3], a mutant variant of green fluorescent protein (GFP).
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