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One Orthodox cleric in England says some Catholics are embarrassed by the idea that he is a priest and see him as a "funny mutant variant of Catholic".
We further excluded entries mapped to a mutant variant of a kinase, e.g. EGFR(L858R).
In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER).
This mutant variant of EGFR is constitutively activated and expressed in approximately 30% of GBM patients.
pCfvtx was constructed with a stop codon flanked by two multiple cloning sites (MCS1 and MCS2) upstream of Venus [ 3], a mutant variant of green fluorescent protein (GFP).
To test the influence of a constitutively active mutant variant of FLT3, we analyzed the LAA expression in an FLT3-ITD+ leukemia cell line.
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(C) Protein levels of wild-type and mutant variants of YeaG assessed by anti-His immunoblotting.
The IPCT/DIPPS activities were assessed in cell extracts of E. coli C43, harbouring wild type or mutant variants of the ipct/dipps gene from A. fulgidus.
However, as expected, a similar decrease in the number of viable bacterial cells was observed after 72 h of N starvation when the ∆yeaG mutant strain was complemented with catalytic mutant variants of yeaG (Fig. 6B).
The most common haplotype is the combination of T786C homozygote wild-type variant with homozygote mutant variants of G5665T (ET-1) and Glu298Asp (eNOS).
(A,B) Growth curves show complementation of the phenotype of the ∆yeaG mutant strain with plasmid-borne yeaG (pBAD18-yeaG), but not with mutant variants of yeaG containing catalytically deleterious mutations in the AAA+ domain (in A. pBAD18-yeaG K116A; pBAD18-yeaG R232A) or eSTK domain (in B. pBAD18-yeaG K426A; pBAD18-yeaG Y382Stop).
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