Sentence examples for mutant to drive from inspiring English sources

The failure of the mutant to drive lymphoproliferation was confirmed in a BMT model for B-ALL.

The ability of the ORAI1 R91W mutant to drive the V419S OASF mutant into a more extended conformation might imply that the intramolecular transition within OASF is coupled to the interaction with rather than the gating/permeation of ORAI1.

The preclinical model developed here (referred to as the 'death-switch') exploits the convergence of apoptotic signalling pathways on caspase-3 and relies on the tightly controlled, doxycycline-inducible activation of a constitutively active mutant of caspase-3 (or an inactive point mutant) to drive synchronous apoptosis in HT29 colorectal cancer (CRC) cells.

These preliminary results suggest that OCs may interact with the ESR1 A908G mutant receptor to drive the development of some breast tumors.

We mutated all of the dTcf, Tin, or Pnt motifs used for prediction of each CRM, as well as the Twi motif used for prediction in notum_cooc310, and assayed the ability of the mutant CRMs to drive reporter gene expression in transgenic embryos.

An aggravating factor to the misfolding of p53 caused by single amino acid mutations is the negative dominance property: several p53 mutants (translated from a single mutant allele) are able to drive wild-type p53 protein (translated from the remaining wild-type p53 allele) into a mutant conformation, 46) in a way that resembles the action of the prion protein.

In conclusion, the promoter heat shocking protein 70(HSP70) regulatory sequence of the construction was shown to drive mutant IκB expression so that its levels were positively associated with the dose of LPS used to induce acute lung injury.

The JNPL3 mouse model utilizes the mouse prion promoter [ 5] to drive mutant human tau expression [ 31].

80 In vitro data suggested that intracellular signaling activated by the 125-kDa mutant form was sufficient to drive neoplasia KIT.

Interestingly, mutant COPA also appears to drive CD4+ T-cells toward TH17 phenotype via increased expression of IL-1β, IL-6 and IL-23 [ 55].

It is known that development and progression of RNA-mediated pathology involve expression of expanded repeats (5– 7, 21, 22, 75) and the presence of mutant transcript is required to drive RNA foci formation (9, 10, 37, 58).