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While the level of housekeeping σD was similar in parent and mutant, the levels of the flagella synthesis regulator σF and the stationary phase regulator σS were higher in the mutant strain, indicating a different motility and stationary phase phenotype.
Indeed, while the accumulation of most miRNAs is strongly reduced in a null ago1 mutant, the levels of miR156/157 and miR167 are unchanged [11].
In this mutant, the levels of rum1 mRNA also increased after tor2 inactivation, indicating that PKA activity was repressing rum1 transcription (Fig. 1C).
For those elements which did show a marked difference when comparing wt and the hma2 hmutantthet, the levels measured are shown in Figure 7.
In case of the SIM2/3 mutant, the levels of tetra-SUMO2 were even higher than in control cells.
Strikingly, in are1Δ are2Δ doa10Δ mutant the levels of ergosterol dropped by more than 50%, while the levels of the intermediates lanosterol and ergostadienol increased dramatically.
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As for cdf1-R mutant, the level of expression of AtMYB60 was not significantly reduced in the cdf2-1, cdf3-1 and cdf5-1 single mutants (Additional file 2).
What is shown in this paper is that, in a fancm mutant, the level of "extra" COs that arise in heterozygous regions is less than in homozygous regions.
In both mcl1 and swi7 mutants the levels of the centromeric histone Cnp1 associated with the central domain are reduced and there is partial loss of the unique chromatin structure of this region.
In dimm mutants, the levels of secretory neuropeptides in the central nervous system are diminished.
Note also that with all PARK2 mutants, the levels of immunoprecipitated endogenous AMBRA1 increased after CCCP treatment.
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