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In this mutant, the differentiation of the epidermis and exodermis is perturbed.
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In Ebf1 null mutants, the differentiation of cells in IC is irregular during the embryonic stage (Garel et al., 1999).
In Lrp4 mutants the differentiation of epithelium into inner enamel epithelium is normal, except for ectopic differentiation of epithelium at the junctions between developing molars.
Class 4 mutants affect the differentiation of vulval progeny and lead to abnormal vulval morphology in L4 larvae and a protruding vulva (Pvl) phenotype in adults.
Finally, we observed correlation between PDGF-PI3K signaling and osteoblast differentiation at E13.5 as well as increased AP staining in Fgfr1 mutants, indicating the differentiation circuit repressed by FGF signaling in MEPMs is functional in vivo.
A common feature of Lhx6 (Liodis et al., 2007; Zhao et al., 2008) and Satb1 (this study) mutant mice is the differentiation deficit of MGE-derived cortical interneurons.
The expression of these markers was also observed in the perineal epithelia of the E9.5-TM-treated β-catenin LOF mutants, indicating that the differentiation of the URS epithelial cells in the β-catenin LOF mutants proceeded normally.
The phenotypic characterization of the nodules along with the analysis of gene expression in the mutants demonstrated that the differentiation of the symbiotic cells and of the bacteroids constitute two key events in the activation of genes during nodulation and the establishment of the "nodule-specific transcriptome".
Mutant is defective in the differentiation of primary sporogenous cells into microsporocytes, and does not properly form the anther wall [ 51, 58, 59].
The possible mechanism is unknown but might reasonably relate to factors secreted from mutant cells that alter the differentiation, migration or function of wild-type cells in the brain.
The differential expression (DE) scatter plots allow to visualize which gene(s) in the differentiation mutants behave like wild-type and which gene(s) differ in bradyzoite induction levels compared to wild-type.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com