The ΔescN EPEC strain is a T3SS ATPase mutant that is devoid of T3SS activity.
The ΔescN EPEC strain, a T3SS ATPase mutant that is devoid of T3SS activity, was used a negative control.
By using a mutant that is resistant to C-terminal cleavage, Bui et al. showed that the N-terminal cleavage can occur independently from the C-terminal cleavage11.
Hall, J.P. et al. The osmoregulatory pathway represses mating pathway activity in Saccharomyces cerevisiae: isolation of a FUS3 mutant that is insensitive to the repression mechanism.
ΔF508 CFTR is a trafficking mutant that is retained in the endoplasmic reticulum (ER) and unable to reach the plasma membrane.
Brucella abortus vaccine strain RB51 is an attenuated, stable rough mutant that is being used in many countries to control bovine brucellosis.
Importantly, restoration of Dok-1 levels strongly suppresses transformation of cells expressing oncogenic tyrosine kinases, and this suppression is more pronounced in the context of a Dok-1 mutant that is largely refractory to oncogenic tyrosine kinase-induced degradation.
Comparison of unliganded wild-type and Lys103Asn mutant HIV-1 RT structures reveals a network of hydrogen bonds in the Lys103Asn mutant that is not present in the wild-type enzyme.
In the relA and spoT double mutant that is unable to synthesize ppGpp, both the las and rhl QS systems are down-regulated, and the production of QS-dependent virulence factors rhamnolipid and elastase are reduced (Schafhauser et al., 2014).
slr1 is a constitutive GA response mutant that is caused by a loss-of-function of DELLA, which is a key factor in the repression of GA responses (Ikeda et al.[2001]).[2001]
The ability of PGC-1 to associate with and potentiate the transcriptional activity of an ERalpha-AF2 mutant that is unable to interact with the p160 class of coactivators suggests that this coactivator may have a unique role in estrogen signaling.
