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There is one other report in the literature of a mutant that increases myofibril diameter, flt H [20].
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This increase was associated with an increasing proportion of isolates typed as containing only the 108N mutant that increased from 1.5% in 1993 94 to 11.8% in 1995 (Fisher's exact test, p = 0.043) and further increased to 30.3% in 1996 99 (Fisher's exact test, p = 0.030) (Figure 2C).
Mutants that reduce neurotransmitter release are resistant to the effects of aldicarb, whereas mutants that increase neurotransmitter release are hypersensitive.
We identified 28 F. novicida transposon mutants that increased the rate of cell death of infected macrophages.
This finding suggested an efficient method of isolating mutants that increase synaptic transmission.
We previously used the ade2 -min3 reporter construct to identify mutants that increase stationary-phase minisatellite instability.
We utilized the ade2 -min3 reporter in a screen for mutants that increased the frequency of minisatellite alterations (Kelly et al. 2007).
Such regulators can be easily identified in live animals as mutants that increase the abundance and/or apical membrane localization of the PGP-3ΔF508 PGP-3ΔF508s measured by fluorescence.
It has been shown that Notch activation is greatly reduced in mutants that block entry into the early endosome but is enhanced in mutants that increase endosomal retention [ 44].
As a result of these different effects, selection favors the fixation of mutants that increase the care of sons (Equation 20) with greater strength than those that increase the care of daughters (Equation 19), especially when fertility is high.
Mutants that increase synaptic activity, or larvae overexpressing pAbp mRNA show increased occurrence of subsynaptic dPABP/eIF4E aggregates, altered levels of some synaptic proteins, significantly larger NMJs and more efficient neurotransmission [ 29], consistent with modified subsynaptic translation.
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