Sentence examples for mutant that inactivates from inspiring English sources

Expressing the ADAR1p150 (E912A) mutant that inactivates the deaminase catalytic site gave the least effective reduction in ISG levels.

Moreover, we found that expression of RhebQ64L, a constitutively active mutant that inactivates TSC2 and activates mTOR, leads to a dramatic upregulation of Pml protein in p53 null MEFs (Fig 3E).

Deletion of the whole ABD in talin did not impair talin function further, consistent with the dimerization helix being essential for actin binding [ 23, 24], and possibly only necessary for this function, because a point mutant that inactivates actin binding but not dimerization is equivalent to one that impairs both [ 18].

To further examine the role of HJ processing, we analyzed a strain carrying the ruvA60 mutant allele that inactivates the RuvABC HJ resolvasome.

Indeed, upon selection ∼1% of the females were weakly fertile, giving a few escaper F1 progeny harboring a variety of mutant alleles that inactivate the remaining restriction site.

However, single deletions of either locus only resulted in a minor effect on bile salt resistance possibly due to mutual compensation of the two loci [ 19], which may also explain why we did not identify these loci in the M-TraM screening, as the mutant library only contains mutants that are inactivated in a single locus by transposon insertion [ 22].

If so, then a mutation that inactivates the mutant protein should revert the dominant suppression of the P[181PRE]8-10C eye color.

Transcription of at least one other gene of the mga regulon, sic, which encodes a protein that inactivates antimicrobial peptides, was also dramatically reduced in ΔdltA mutants.

An increase in the levels of DIAP1 protein, a key inhibitor of cell death in Drosophila, has been commonly observed in mutants that inactivate Hippo signaling [13, 50, 51].

This enzyme is a glycosidase that inactivates ribosomes.

Cln3-Cdc28 also inactivates Whi5, the transcription suppressor that inactivates SBF specifically by direct binding until G1 [25], [25].