Sentence examples for mutant that failed from inspiring English sources
If MCAK localization depends on its interaction with TIP150, the phospho-mimicking mutant that failed to localize to the plus end could disrupt the MCAK TIP150 interaction.
Interestingly, one mutant that failed to express functional channels in our hands (K978C) has previously been studied in a Cys-less background by patch clamp recording by others (see below).
While mDHFR fused to wild-type CARD appeared in inclusion bodies due to CARD oligomerization, it remained soluble when it was fused a CARD mutant that failed to oligomerize.
Identification of the interaction domain in p62 and application of the p62 mutant that failed to interact with Keap1 allowed us to determine that the formation of the complexes is initiated by HBx, and p62 has a pivotal role in bridging HBx and Keap1.
Although the Mdm2 protein binds to p53 to mediate p53 proteolysis, the effects of Mdm2 on TGF-β sensitivity appear to be independent of p53 function, because expression of an Mdm2 mutant that failed to bind p53 also conferred resistance [ 105].
This question was addressed by determining if RVF-VLPs could be produced when RdRp was absent or when the Gn mutant that fails to recruit RdRp (GnK48) was expressed.
Instead, foci disassemble more rapidly in a point mutant that fails to bind Rad51, associated with faster mitotic entry.
Analysis of the sgo1-700 muthat that fails to associate with condensin provides strong evidence that Sgo1 promotes the bias to sister kinetochore biorientation through condensin recruitment.
This might be the only AF-linked Cx40 mutant that fails the 'quality control' mechanisms in the ER, resulting in its retention in this organelle.
The use of the mutant that fails to undergo growth cessation evg as a biological filter in controlled conditions has allowed us to reduce the number of genes detected by typical differential display experiments during growth cessation and dormancy.
Here we report on an ethyl-methane sulfonate-mediated Arabidopsis mutant that fails to induce [Ca2+]cyt elevation in response to exudate preparations from the pathogenic mibrobes Alternaria brassicae, Rhizoctonia solani, Phytophthora parasitica var.
