Sentence examples for mutant that abrogates from inspiring English sources

However, we observed comparable LYN binding to the W232A mutant that abrogates its interaction with PEST family phosphatase.

We found that Fps13A was at least as arsenite resistant as any other mutant that abrogates Fps1 function.

However, most of the mutants that abrogate STIL-CC/ PLK4-PB3 interaction do not promote centriole amplification when overexpressed.

Conversely, a mutant G306ECbl that abrogates c-Cbl RTK interac-Cbl RTK shown to protect human MSCs from apoptosinteraction

The first demonstration that c-Cbl controls osteoblastic cell proliferation came from our finding that the expression of a mutant G306ECbl that abrogates the interaction between c-Cbl and RTKs increases human mesenchymal stromal cell (MSC) proliferation.

This hypothesis is supported by our finding that a mutant G306ECbl that abrogates c-Cbl-RTK interaction in human MSCs decreased FGFR2 and PDGFR- α receptor ubiquitination and degradation, resulting in increased expression of these receptors and activation of downstream ERK1/2 and PI3K signaling pathways that in turn promoted osteoblast differentiation and in vitro osteogenesis.

In contrast to the Nup53 mutants and truncations that abrogate one membrane binding region, mutants affecting both membrane binding sites (1 319 R105E/K106E, 1 319 S94E/T1 312 1–312 R105E/K106E and 1 312 S94E/T100E) did not support NPC assembly and NE reformation.

To resolve whether increased H+ efflux by Dnhe2 is necessary for disrupted tissue architecture we generated transgenic flies expressing a mutant Dnhe2 E358I, analogous to the NHE1E266I mutation that abrogates H+ efflux (Denker and Barber, 2002).

But recognition of misfolded htt by gp78 still requires the cue domain, since mutation of the cue domain that abrogates gp78-htt interaction failed to target mutant htt for degradation.

A mutant version of the MRTF-A(2 204)–2GFP protein containing a mutation that abrogates actin binding (Vartiainen et al, 2007; Guettler et al, 2008) was efficiently imported into nuclei in vitro, but was insensitive to LatB actin addition.

Infection with neither of the two mutants that abrogated the combined expression of P78 and NSm or NSm′ (AUG 1+2 KO and AUG 1+3 KO) led to an attenuated phenotype.