Sentence examples for mutant structures bound from inspiring English sources

However, despite this clear coordination geometry, elements of the J−K loop remain disordered in both wild-type and mutant structures bound to diphosphate containing ligands with Y527 electron density missing from the active site.

The collective dynamics of mutant structures of the protease bound to p1-p6 and NC-p1 substrates are assessed using the Anisotropic Network Model (ANM).

To determine if the Tyr side chain position is the sole determinant of the isoform-dependent inhibitor binding mode, we have prepared the eNOS Y477A mutant and determined crystal structures of the mutant bound with two inhibitors that do not disturb the Tyr477 rotamer in wild type eNOS.

Energy minimization of mutant structures was performed with Phenix46.

We first assessed the effects of the A481T mutation on Ago2 by determining the crystal structure of the mutant protein bound to a short target RNA bearing a t1A nucleotide (Table 3).

An X-ray crystal structure of the K86R/G100T mutant protein bound to a DNA duplex containing the C G+4 substitution suggests how sequence specificity of a homing enzyme can increase.

The mechanistics of this was further refined by high resolution co-crystal structures of wild type and mutant UNG bound to U : A and U : G oligonucleotides (Parikh et al., 1998).

A similar α-helical structure of a non-toxic doc mutant (H66Y) bound to phd antitoxin (3dd7) replaces the permuted fic α-helix with an α-helical segment of phd.

High-resolution crystal structures have been reported of T. thermophilus Ago catalytic mutant proteins bound to 5′-phosphorylated 21 nt guide DNA and complementary target RNAs of 12, 15, and 19 nt in length.

For comparison, we determined the structure of the A481T mutant bound to a target bearing a t1G nucleotide.

This model was supported by 'superclamp' and 'poor-clamp' mutations that enhanced or decreased the complexin-I inhibitory activity in cell cell fusion assays, and by the crystal structure of a superclamp mutant bound to a synaptobrevin-truncated SNARE complex.