Sentence examples for mutant strains aged from inspiring English sources

As the ATPalpha CJ mutant strains aged the progressive nature of this locomotor defect became evident with all lines exhibiting marked paralysis that resulted in a significantly longer recovery time than age-matched controls and with young animals of the same genotype (Fig.  7a).

However, the double mutant afo1Δ, tor1Δ strain aged more rapidly than the single mutant afo1Δ strain.

Using prematurely aged mutant strains holds the promise to dramatically facilitate these studies.

The results are strongly influenced by two mutant strains (daf-2 and age-1) that show the greatest longevities.

We compared the expression of mai-1 and mai-2 (which has a mitochondrial import signal) in 2- and 8-day-old adults using qPCR and found no difference between the WT and daf-2 mutant strains nor between the age classes (results not shown).

To overcome some of the limitations inherent in correlative ageing cohort studies, mutant strains have been generated by perturbing antioxidant systems with the aim of modulating oxidative damage.

Our chemical genetic screen identified LCA as a compound that under CR conditions extends the CLS of pex5 Δ, a prematurely aging mutant strain displaying profound changes in lipid metabolism, lipid-induced necrotic cell death, mitochondrial morphology and functions, stress resistance, mitochondria-controlled apoptosis, and stability of nuclear and mitochondrial DNA.

In order to test whether miRNAs displaying age-specific abundance modulate lifespan, we tested mutant strains for several of the candidate miRNAs.

To ensure that the aging studies were performed with isogenic strains, bcIs78 males were crossed with hermaphrodites of the different mutant strains used in the study.

Pedigrees of some mutant strains of Escherichia coli K-12.

Next, we infected A. castellanii with these mutant strains.