Sentence examples for mutant status of from inspiring English sources

In this line, mutant status of p53 might be involved in the pathway of the inhibition of OUMS-27 cell growth by PPARγ ligands.

We also found association between the occupational exposure to pesticides with that of the mutant status of SMAD4 gene (P =< 0.05) identifying it as a potential risk factor.

The mutant status of KRAS and SMAD4 gene was found to be significantly associated with the higher tumor grade (C+D) (P value = 0.03).

Another study showed that among patients with the T/T genotype, mutant status of TP53 and aberrant p53 protein expression were associated with poor survival, suggesting an interaction between MDM2 SNP309 and tumor TP53 status [ 25].

The involvement of miRNAs in the mutant status of EGFR and the emerging role of these molecules in the regulation of the EGFR signaling pathway and drug resistance to anti-EGFR agents have made miRNAs potential biomarkers for the diagnosis and prognosis of lung cancer, as well as potential predictive markers for the therapeutic outcome using anti-EGFR agents or regimens.

In order to address the ability of the discriminant variable to predict the RAS mutant status of cell lines based on a pre-determined DFA CV1 cut-off, data were reanalysed by randomly selecting a training set (50% of the samples, used to produce the DFA plot based on the selected features) and a test set (the remaining samples).

In addition, we determined the VHL mutant status for most of the cell lines and the level of expression for lines with wt-VHL (Table 2).

As such, the lowest measured mRNA output in each cluster is assigned to the "all off" state (Experiment 0 in Table 4), regardless of the mutant status and is representative of the background mRNA level.

46 Post-hoc KRAS analyses of 69% of tumors detected KRAS mutant status in 42% of patients.

We have also observed a statistically significant association of SMAD4 gene aberrations with KRAS mutant status suggesting the involvement of at least two molecules in the advanced tumor grade in colorectal cancers; in other words, in case of high grade advanced tumor, aberration in more than one molecular gate keeper of several signal transduction pathways may be involved.

A similar increase in caspase 3/7 activity was reflected in the apoptotic index of A549 parental cell, or its other two mutant status, suggesting that the addition of atorvastatin significantly enhances the same concentration of gefitinib for reaching the threshold of caspase activation and apoptosis in KRAS mutant alone, or in the comutant KRAS/PIK3CA or KRAS/PTEN status of A549 cells.