Sentence examples for mutant spectrum with from inspiring English sources
Such a bipartite particle system (with two classes of genomes with internal deletions, but consisting of a mutant spectrum, with multiple minority genomes with non-identical internal deletions [6]) can be regarded as a candidate anti-FMD vaccine.
A broad hepatitis C (HCV) virus mutant spectrum was associated with poor response to treatment by ribavirin and interferon α [ 9], and rapid early evolution of the virus led to a chronic infection [ 10].
To determine whether the mutant spectrum of V3A included genomes with the same mutations found in the other lineages, the P2 P3 coding region of virus isolated from 5 individual plaques derived from population V3A at passage 1 was sequenced.
Replicative fitness relates to an optimal mutant spectrum that provides the molecular basis for phenotypic flexibility, with implications for antiviral therapy.
To check whether the mutations contained in the site-directed mutants assayed can fix when present in a simple mutant spectrum, we carried out competition experiments of these viruses with the virus Qβwt.
The mutation profile in the components of the mutant spectrum of each population analyzed indicated that a specific pattern of mutations was associated with each mutagen.
We have reconstructed a foot-and-mouth disease virus (FMDV) quasispecies, with two matched pairs of distinguishable mAb-escape mutants as minority genomes of the mutant spectrum.
Large population sizes coupled with high mutation rates during viral replication result in increased genetic diversity within the mutant spectrum [ 17].
Analysis of the mutant spectra of virus populations selected with different concentrations of antibody in infections in liquid culture medium has documented a dominance of the high fitness counterpart in the selected population.
These results motivated us to investigate how the complexity of the mutant spectra generated at increased error rate interferes with the fixation of beneficial mutations.
Similarly, in vivo studies with WNV demonstrate that the large mutant spectra generated during mosquito infection are maintained during host switching [10].
