Sentence examples for mutant retains only from inspiring English sources

This unique loss-of-function mutant retains only nuclear functions and sits in a pocket, outside ATP and substrate binding region, that is suited for designing allosteric inhibitors of IGF1R.

Indeed, steady-state kinetic studies have shown that the FlK-T42S mutant retains only ∼200-fold selectivity for fluoroacetyl-CoA over acetyl-CoA, an effect that is partially attributable to a 30-fold decrease in the KM for acetyl-CoA.

A critical role for the C558′/C559′ pair in Hg2+ transfer and/or reduction was initially suggested by the observation that the CCAA mutant retains only 0.09% of the steady-state catalytic activity of the wild type (CCCC) enzyme with typical Hg SR 2 substrates.

Enzyme specific activity values obtained for each protein reveal that the PLCζH233L mutant retains only 24% of the activity of wild-type PLCζ (157 ± 48 vs. 655 ± 36 nmol/min/mg), and the PLCζH398P mutant almost completely fails to hydrolyze [H]PIP2.

The additional T60D and S64D mutations mediated progressive loss of RPA binding, and the triple S23D/T60D/S64D mutant retained only about 40% of the RPA-binding capacity relative to WT UNG2.

In contrast, dfp1-r35 mutants retain only about 2% spore viability.

Mutants retain only rudimentary glands or lack them entirely and show defects in sperm storage and egg laying (Anderson, 1945; Allen and Spradling, 2008).

As both mutants retain only one of the C-terminal cysteines, they can only displace one free thiol from the incoming Hg SR 2 substrate, and then must drag the other bound ligand as far into the dimer cleft as possible for C136 to initiate attack on the mixed enzyme Cys-Hg-SR complenzyme Cys-Hg-SR

The M8 mutant, which retains only 3 of the 5 intracellular tyrosines, also undergoes tyrosine phosphorylation.

The model is that Nadrin2 recruitment suppresses Rac1 activity important for filopodial extension, and this model is supported by weaker phenotypes of a Nadrin2 mutant that retains only weak Rac1 GAP activity.

The Sec → Cys mutant of TR1 retains only 2% of the specific activity of the WT enzyme, and the mutants that contain only a partial C-terminal redox center retain only 1% of the activity of the WT enzyme (compare enzymes 3 and 15 with enzyme 1).