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Using this method, we identify a novel mutant resistant to Al. Physiological analysis reveals that decreased Al binding capacity to the cell wall is responsible for the increased resistance of ral1 mutant to Al. RAL1 gene is mapped on the long arm of chromosome 6, and cloning of the gene is currently undertaken.
Native Gap1 and the Gap1K9,16R mutant resistant to ubiquitylation were used as controls (Fig. 4C).
Notably, the L100I/K103N double mutant resistant to Efavirenz had reduced susceptibility to MIV-150.
A Chinese hamster ovary cell line mutant resistant to several bacterial ADP-ribosylating was obtained by this approach.
However, the Y181C mutant resistant to Nevirapine remained fully sensitive to MIV-150 (0.2 nM vs 0.7 nM against wild type).
IκBαΔNTg mice exhibited a striking defect in thymic STAT5a activation [70], and NF-κBSSAA/SSAA Knock-in mice, expressing a p105 mutant resistant to signal-induced degradation, also displayed a IL-2R signaling defect in peripheral T cells [56].
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These are comprised of data on the numbers and resistance properties of mutants resistant to each of the drugs.
For mutants resistant to ≥4 × MIC of ciprofloxacin, the AUC24/MIC was less predictive of the AUBCM than the AUC24/MPC ratio.
Antibiotics in the waste can lead to the emergence and spread of mutants resistant to antibiotics, which would threaten the safety of food and human health.
BVDV mutants resistant to lead compounds in our series were then isolated, and the mutant residues on the viral molecular target, the RNA-dependent RNA-polymerase, were identified.
Accordingly, BVDV mutants resistant to lead compounds in our series were isolated, and the mutant residues on the viral molecular target, the RNA-dependent RNA polymerase, were identified.
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