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From a theoretical perspective, each mutant represents a possible fault that could be present in the original system (Copeland 2004).
Thus, the M. tuberculosis ΔsecA2ΔlysA mutant represents a live attenuated TB vaccine strain with the potential to deliver increased protection and safety compared to standard BCG vaccination.
Therefore the double mutant represents a carbohydrate-starved plant.
Thus, we concluded that the Ser291A/C163E double mutant represents a dominant-negative mutant of Taspase1.
The sgn3 mutant represents a powerful new tool to better understand root uptake and transport mechanism of most other plant nutrients as well.
In contrast to wild-type LIG4, the S205LfsX29 LIG4 mutant was only expressed in the cytoplasm (Fig. 2B), which indicates that the S205LfsX29 mutant represents a null mutation.
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The hyh mutant represents an ideal animal model to investigate how do the brain "adapt" to a virtually life-lasting hydrocephalus.
Next we analyzed the aPKCζ R140E/G141E mutant representing a NLS deficient aPKCζ variant.
The cat2 doubleouble mutant represented a case where both of the single mutants are LMMs (Additional file 7: Figure S6).
The upper right quadrants for each TR mutant represent a number of transcriptionally altered but non-functionally clustered genes.
Therefore, signaling by the Walker A mutants represents a bona fide response to exogenous RNA, and we conclude that ATP hydrolysis is not required for signaling by RIG-I on a high-affinity RNA ligand.
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