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10.7554/eLife.01566.023 Figure 8. dyf13 mutant reduces the levels of inner dynein arm components in its flagella.
The lpr-cg mice Fas mutant reduces the level of binding to FADD, which could be due to an altered structure.
Collectively, the I130T mutant reduces the phosphorylation of total Cx43 and Cx43 gap junction plaques, with no obvious effect on other co-expressed mammary gland connexins.
Considering that the A673T mutant reduces the production of Aβ, it might be interesting to evaluate if a correlation exist between the presence of the mutation and an eventual higher risk to develop some forms of encephalomyelistis.
It was also reported earlier in A. thaliana that amino acid permease AAP6 mutant reduces the amino acid level in phloem sap and this correlated with the aphid behavior [ 49].
By using a double-referenced single chain model (see 'Materials and methods'), we estimated that the destabilisation of the intermediate in the N44A mutant reduces the koff by a factor 3, while changing the Kd by a factor 1/3.
In contrast to 45OX transgenic rice that increased the expression of OsMADS14/18 and Hd3a/RFT1 and caused early flowering, a study using MADS14/15/18 i-pap2-1 quadruple knockdown mutant reduced the expression of Hd3a/RFT1 and resulted in delayed flowering (Kobayashi et al. 2012).
Individual mutations of F313 or F314 to Ala caused 25 50% reduction in the initial rate of permeabilization, and the double Ala mutant reduced the initial rate ∼3-fold.
In Enterococcus faecalis, analysis of three mutants [26] which lack NADH peroxidase, alkyl hydroperoxide reductase and thiol peroxidase revealed that the viability of the tpx mutant reduced the most in response to oxidative stress and growth in macrophages.
We found that the presence of the kinase-dead Akt mutant reduced the amount of Bcl-w linked to the mitochondrial fraction and induced only a slight increase in the cytosolic one (Figure 3B).
The presence of the kinase-dead Akt mutant reduced the amount of Bcl-w linked to this fraction, but it did not increase Bcl-w in the cytosol; we obtained similar results with cells transfected with Akt siRNA.
