Sentence examples for mutant proteins when from inspiring English sources

We subsequently measured the ATP binding affinities of WT RIG-I and mutant proteins when bound to 5′ppp30L.

2) The authors consistently refer to "mutant" proteins when they are actually characterizing proteins that have amino acid substitutions, not mutations.

In Drosophila models of these diseases, the benefits of rapamycin appear to be autophagy dependent, as this drug had no effects on the proteinopathy toxicity in flies expressing these mutant proteins when the activity of different autophagy genes was reduced (Berger et al., 2006; Pandey et al., 2007; Wang et al., 2009).

The mutant protein, when expressed in AECs, was not excreted but retained in the ER and induced ER stress [ 35], a process similar to that seen in SFTPC mutants.

Previously, we have shown altered localisation of this mutant protein when re-expressed in TSC1-null urothelial cells and unlike other somatic missense mutants, there is no splicing defect or reduced protein stability [ 58] pointing to altered function (possibly dominant negative) rather than haploinsufficiency in this case.

These similarities strongly argue that the mutant human proteins, when expressed in C. elegans, are closely modelling a fundamental property of these mutations in humans.

The disease is believed to be caused by a mutant protein that, when eaten, travels through the body to the brain.

Computational modeling of mutant protein structures when compared to WT kinesin showed substantial differences in conformational flexibility and ATP-binding efficiency.

And, although the effects might be subtle, a phenotype could be exacerbated when other mutant proteins are expressed, or when cells are exposed to stress, or as an organism ages (Jarosz et al., 2010).

Changes in thermal stability of MftR and mutant proteins were equivalent when measuring Tm for stoichiometric ratios of protein and DNA representing either cognate site (mftrO and mftpO).

For instance, the UPR is induced when mutant proteins cannot be properly folded and accumulate within the ER lumen.