Sentence examples for mutant proteins including from inspiring English sources

Since the first publication in 1998 of the structure of a recombinant soluble protein comprising the ligand-binding domain of GluA2 extensive studies have afforded numerous crystal structures of wildtype and mutant proteins including different ligands.

Tse and others in 2004, targeted amino acid residues within the ICAM-1 protein and introduced alanine mutations that resulted in 25 mutant proteins, including ICAM-1S22/A, in which serine at position 22 is replaced by alanine.

This is due, at least in part, to an increased susceptibility of the 57-146 disulfide bond to reduction in many mutant proteins, including A4V, G93A, and G85R, as demonstrated previously [30].

ProTherm is a collection of experimental thermodynamic parameters for wild-type and mutant proteins, including the change in Gibbs free energy.

We note that we were able to find one report in the literature in which inducible vectors were used in mouse NSC-34 cells to express a limited number of human mutant proteins (including A4V, C6F, H46R, G93A, C146R) (41).

The mutant proteins included L55P, a highly amyloidogenic variant found in ATTRm patients with early onset familial amyloid polyneuropathy, and F87M/L110M (monoTTR), an engineered variant that is present mostly in monomeric form at neutral pH.

Since the discovery that mutations in the enzyme SOD1 are causative in human amyotrophic lateral sclerosis (ALS), many strategies have been employed to elucidate the toxic properties of this ubiquitously expressed mutant protein, including the generation of GFP-SOD1 chimaeric proteins for studies in protein localization by direct visualization using fluorescence microscopy.

Both rapamycin (a specific mTOR inhibitor) and drugs acting on mTOR-independent pathways enhance the clearance of mutant polyglutamine proteins (including full-length mutant ataxin-3) in cell culture (Sarkar et al., 2005; Berger et al., 2006; Williams et al., 2008).

We have made 7 mutant E7 proteins including C94V mutation.

It was demonstrated that various mutant polyQ proteins (including mHttex1) can form soluble oligomers before IBs appear [18].

Based on prevailing models, Type 2B mutant pVHL proteins, including R167Q, are predicted to disrupt VBC complex formation by eliminating Elongin C binding to pVHL [13], [27] [30].