Sentence examples for mutant proteins associated from inspiring English sources

We have also shown that rapamycin promotes the clearance of other intracytoplasmic, disease-associated, aggregate-prone proteins, including mutant proteins associated with spinocerebellar ataxias, mutant forms of α-synuclein implicated in PD, and mutant tau responsible for FTD, thereby attenuating their toxicity (Berger et al., 2006; Menzies et al., 2006; Williams et al., 2006).

One of the most studied mutant proteins associated with familial ALS cases is the Cu/Zn superoxide dismutase protein, SOD1.

Autophagy is considered to be a selective and efficient mechanism for the degradation of misfolded and mutant proteins associated with neurodegenerative diseases including amyloid precursor protein (APP), α-synuclein, superoxide dismutase-1 (SOD1) and many others.

We show also that ΔNp63α protein stability is negatively regulated by the interaction with the prolyl-isomerase Pin1, via proteasome-mediated degradation; p63 mutant proteins associated with SHFM or EEC syndromes are resistant to Pin1 action.

This was the first dominant gain-of-function neurodegenerative disease model to be studied in zebrafish, and validated the use of this animal model for experimental investigation while providing evidence that early changes in neuronal structure could arise in vivo following expression of mutant proteins associated with SOD1 pathology.

Future development programs of individualized cancer immunotherapy include analysis of a wide range of variant antigens observed in each cancer, such as mutant proteins associated with point mutation, translocation, and splicing variant, for the production of cancer vaccines or effector cell therapy that can attack variant neo‐antigens unique to each patient.

Both the mutant protein associated with the c.1A>G and the p.Gly2891Asp mutant protein are shown in Figure 6A.

As indicated in the manuscript, there is less mutant protein associated with the membrane fraction because of reduced translocation.

Results The authors studied the development of Kv3.3-expressing motor neurons in the zebrafish spinal cord after exogenously expressing the wild-type Kv3.3 protein, or a mutant protein associated with early-onset disease, or a mutant protein associated with late-onset disease.

To test the hypothesis that the putative SMCX PIP box mediates the interaction with PCNA and loading SMCX onto chromatin, we mutated three of the conserved residues within the PIP box (F, L and Q; Figure 6), and investigated whether these mutant proteins associate with PCNA and chromatin.

To correlate binding of NF-Y to gene expression, and the presence of active histone marks, we infected human HCT116 cells with an NF-YA dominant negative adenovirus (Ad-YA-DN) containing a mutation in the DBD subdomain (YAm29): the mutant protein associates with the histone fold dimer and renders the trimer incapable of CCAAT association [33 and References therein].