Therefore, our data demonstrate that Nde1 is functionally essential during S phase and that DNA damage in Nde1 mutant progenitors results from stalled and catastrophic DNA replication.
The reduction of neural progenitors during early stages of corticogenesis in the Nde1−/− Lis1+/− mutant was confirmed by a series of developmental studies.
Chabab, S. et al. Uncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesis.
NeuroD6 restricts the proliferation potential of committed neural progenitors during neurogenesis19,20,21.
Mchedlishvili, L., Epperlein, H., Telzerow, A. & Tanaka, E., A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.
Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.
NBC involves targeted ablation, mediated by diphtheria toxin subunit A, of host-derived dorsal telencephalic progenitors during development.
Lescroart, F. et al. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.
Caprioli, A. et al. Nkx2-5 represses gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis.
Further, knowledge from studying embryonic progenitors during kidney development may be directly relevant to adult cell types, as multipotent renal progenitors isolated from adult kidneys could represent a subset of embryonic progenitors that persist from early nephrogenesis.
