Indeed, separate biopsies from H3 mutant HGA showed similar mutational profiles (including H3.3 K27mutationon) and close to identical global DNA methylation patterns, with heterogeneity seen largely for copy number variants in growth regulatory genes, such as PDGFRA amplification [ 19].
The complete dataset of the 636 yeast mutants identified in our genomic profiles including information about their degree of growth alteration is described in Additional file 2. Two previous genome-wide phenotypic analyses using CAS have been published [ 28, 29].
These transcriptional profiles included regulatory mutants of S. aureus and growth of wild type under different growth conditions.
This soybean line was selected to contain three mutant alleles affecting the fatty acid profile, including FAD2-1A Δ alleles from M23, and mutant FAD3A and FAD3C alleles from soybean line 10-73 [ 21, 36].
Intel VTune Performance analyzer assists in various kinds of code profiling including time-based profiling, event-based profiling.
As shown in Table 2, the GALC mutational profile was highly heterogeneous, being characterized by a total of 33 distinct mutant alleles including 15 previously unreported alleles; three mutant alleles still remain to be identified.
The ionomic profile of this mutant shows repeatable alterations in multiple ions in the mutant leaves including reduced levels of Mo, Mn, and Mg and increased levels of K and Zn.
Further, we identified and discussed several elongation-related genes that exhibited altered expression profiles in the Li 1 mutant, including a putative primary cell-wall related cellulose synthase.
Using whole transcriptome profiling of gene expression and splicing by RNAseq in dissected epidermis, they identify many changes in splicing in the mutant epidermis, including many known ESRP targets.
In addition to the wild-type cueO, we also identified 14 cueO mutants, including eight mutants containing the synonymous mutations and six mutants containing the non-synonymous mutations.
