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The values in heat map array and corresponding posterior mutant probability were calculated by the following formulas: (4) P p A i | O i = P r A i × P O i | A i ∑ i P r A i × P O i | A i (5) H = log 10 P p N C | O i + P p C C | O i P p N N | O i A i is one kind of the three genotypes (NN, NC, CC for homozygous normal, heterozygous mutant, homozygous mutant, respectively) in the site of each cell.
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This in itself is not surprising given that larger values of the growth potential and division radius will increase the mutants' probability to divide.
For non-neutral mutants, probability of invasion is a monotonically decreasing function of N which saturates for large values of N. In our experiments, we used 2D grid size 21 × 21.
Significantly higher frequencies of abnormal patterning were detected in the muscles of tw mutants (probabilities for all compared pairs were p<0.001, Fisher's exact test) (Fig. 3I).
P p A i | O i is the mutant posterior probability of A i on the observation of O i. Pr Ai ) is the priori probability of A i calculated from the corresponding site at normal tissue.
In this paper, we examine how such dynamic landscapes can alter mutant fixation probability and time to fixation.
This bacillus divides and at each division may create a resistant mutant with probability β, which for isoniazid resistance is on the order of 10−8 [8].
When a resident cell divides, one of the two daughter cells can receive an additional driver mutation (making it a mutant) with probability u (Fig. 1).
Since the second barrier is weaker than the first for the Q3 mutant, the probability for the molecule to pass both barriers simultaneously is increased, thus resulting in a high percentage of single events".
Since the second and final energy barrier for complex dissociation is weaker than the first for the Q3 mutant, the probability for the molecule to pass both barriers simultaneously is increased, thus resulting in a higher percentage of single events.
We note that in these mutants the probability of UNC-40 localization and of axon outgrowth in the ventral direction is low.
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