Sentence examples for mutant phenotypes when from inspiring English sources
As in humans, both L44 and Q45 are largely silent when heterozygous, but exacerbate mutant phenotypes when expressed in trans with R388.
We predicted that if the Bur or Ctk complexes shared a functional overlap with CUS2, as is the case with P-TEFb and Tat-SF1, we might observe synthetic mutant phenotypes when mutations in the Bur or Ctk complexes were combined with deletion of CUS2.
Our study has revealed that C. elegans TF genes conserved across multiple phyla are more likely to be associated with mutant phenotypes when compared to the remaining TF and non-TF genes.
Of course, this kind of experiment requires high sensitivity by the experimenter in order to distinguish between a real phenotype from a side effect, which can be helped by comparison with known mutant phenotypes when these are available.
Our goal was to develop an automatic method for finding parameter values that capture nearly all the mutant phenotypes when starting from an educated "initial guess" of parameter values.
The analysis of the relationship between gene function and interactions revealed that TF genes conserved across phyla exhibit greater number of interactions and mutant phenotypes when compared to those that are divergent.
CLE1 was selected as it complements the clv3-1 mutant phenotype when expressed under the control of CLV3 regulatory elements in transgenic plants [ 35].
This system is buffered by Lgl (LGL-1 – WormBase), which localises to the posterior cortex like PAR-2, and, although non-essential, can rescue the par-2 mutant phenotype when overexpressed (Beatty et al., 2010; Hoege et al., 2010).
The Sas-4-GFP construct appears to rescue the sas-4 mutant phenotype when expressed from the endogenous promoter, as the flies are fertile and coordinated (Novak et al., 2014).
To corroborate the hypothesis that increased proliferation is necessary for niche competition by CySCs and to determine which pathways are normally active in CySCs, we examined other cellular growth and proliferation factors for their ability to rescue the ptc mutant phenotype when reduced.
acdXΔ did not have an effect on the areA217-mutant phenotype when acetamide was used as the nitrogen source, further supporting that AcdX has a specific role for acetate repression of the proline metabolic pathway.
