Since the mutants originate from a directed evolution experiment and are functional, the data provide an evolutionary snapshot of how a protein structure can respond to mutations while maintaining a functional molecular architecture.
Normally when thinking of artificial neural networks (ANNs), the mind's eye explodes with predictably trippy images of puppyslugs and other computer-generated mutants originating from Google's so-called Inceptionism program.
Two R118K mutants originated from successive years (2007 2008), which could indicate that this mutation was established in the wild virus population.
The clinical isolate D7S, which was used as the host strain of the tad-locus single gene mutants, originated from a 28-year-old African-American female (USA) with generalized aggressive periodontitis [31].
The identities of the selected mutants originated from ATCC 17978 were confirmed using pulsed-field gel electrophoresis (PFGE).
Results from this study instead suggest that transporter-mediated NO 3 - accumulation in NR deficient mutants, originating from traces of nitrate in the media, is responsible for the constitutive expression of NirA-regulated genes, and the associated phenotype is thus termed "pseudo-constitutive".
Our data strongly suggest that the hydrocephalus phenotype in Pkd1 mutant mice originates from the third ventricle, the first compartment to develop ciliated ependyma, and subsequently expands to the lateral ventricles.
The CrygbS11R mutant allele originated from the AJ strain background displayed an 112 bp PCR fragment while the wild-type Crygb allele from the C57BL/6J strain background yielded a 143 bp PCR fragment.
Recently, an orange-pericarp mutant (MT) originating from Guanxi pummelo has been discovered in China and provided us a potential material for studying this regulation mechanism.
Gadd et al. analyzed 224 tumours and proposed that WT1/β-catenin mutant tumours originate from the intermediate mesoderm, whereas the WT1/β-catenin wild-type tumours would originate from the metanephric mesenchyme.
