Sentence examples for mutant or functional from inspiring English sources

These populations may be complemented by access to mutant or functional genomics populations as well as more specialized resources such as libraries of introgression lines or CSSLs.

Activation of mutant RB or functional loss of RB and PTEN in the TRP orthotopic model mimicked the alterations observed in human GBM, and allowed us to examine the relative importance of inhibiting the PI3K and MAPK pathways in vitro and in vivo using drugs that are currently in clinical trials for the treatment of GBM (Bendell et al., 2012; LoRusso et al., 2010).

Nevertheless, in the absence of available DCL1 mutants or any functional test, some of these novel potential miRNAs could be difficult to distinguish from the abundant siRNAs that derive from repeated or retroelement sequences or from complementary antisense RNAs [ 9, 15].

The amount of either wild-type or functional mutant forms of CX3CR1 that were expressed by MDA-436 breast cancer cells at the plasma membrane level were measured by cell surface biotinylation, using a dedicated kit (cat. #89881) obtained from Pierce (Rockford, IL, USA) and according to the protocol provided by the manufacturer.

We engineered cells to over-express either wild-type or functional mutants of CX3CR1 as well as employed transgenic mice knockout for fractalkine.

The selection criterion was used to classify each mutant as functional or nonfunctional.

Both proteins were characterized using mutant plants and by functional expression in yeast or functional complementation of yeast mutant strains.

Thus, there is no evidence to suggest that cilial morphology or transport is grossly disrupted in hitchhiker mutants, although more subtle structural or functional defects would not have been detected.

In this study the effects of SN-38 on colon adenocarcinoma cell lines expressing wild-type p53 (LS174T) or mutant non-functional p53 (have) have been investigated.

Therefore, characterisation of these different ALK mutations is an important exercise in assessing whether the various mutants are functional or not, with potential importance for the patient to be treated accordingly.

To score the mutants as functional or nonfunctional, we compared their gain in absorbance minus the median null control reading to that of the median parental control reading minus the median null control reading.