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Although the inhabitants of Pringles had never seen a mutant of this kind, they were mainly country folk, familiar with the principles of procreation.
A spontaneous rifampicin-resistant mutant of this bacterium was marked with the disarmed transposon, Tn7::lacZY.
Expression of a non-phosphorylatable mutant of this site (T794A) in zebrafish (Danio rerio) significantly disrupted vascular development, resulting in fish with stunted and poorly branched intersomitic vessels.
In rice, a mutant of this gene, named c68, carries a nonsense mutation in the kinase domain (Huang et al. 2012).
We also identified a T-DNA insertional mutant of this gene (mtd1 1), which has a T-DNA insertion in the sixth exon (Fig. 6b).
In a competition experiment between wild-type strain Nissle 1917 and a mutant of this strain with a deletion in the yersiniabactin operon, the wild-type overgrew the mutant at pH 7.0 and 7.6 and not at pH 5.6.
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Siderophore-null mutants of this species can invade in vitro populations and cheat their way to high density, resulting in population reduction (Griffin et al., 2004; Table 1).
However, designed mutants of this enzyme capable of degrading organophosphates have to be engineered to enhance their thermostability.
Moreover, data obtained with deletant mutants of this family of proteins indicates that they have potential as targets for novel antifungals.
This apparent global suppressor effect suggests that increasing the thermodynamic stability of p16 can be used as a general strategy to restore the biological activity to defective mutants of this important tumor suppressor protein.
Here we show that analysing the unfolding thermodynamics of single-point mutants of this chimeric fusion protein constitutes a very useful approach to deciphering the thermodynamics of SH3 ligand interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com