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The first detects androgenic compounds using yeast cells carrying a green-emitting P. pyralis luciferase regulated by the human androgen receptor and a red mutant of the same species as internal vitality control.
Most recently, another group has published a paper on the fly mutant of the same gene, but generated differently from a different P-element mutant origin, and their mutants have the same phenotype as ours [19].
We now extend this analysis to show that another mutant of the same type (M183K) exhibits a very similar pattern as M183L.
On the contrary, neomorphic mutations that result in the generation of a gene product with novel biological functions can show a more severe phenotype as compared to a null mutant of the same gene.
In contrast, an Arg98Cys and His102Met double mutant of the same protein, cyt b562, shows 6cLS bis-Met axial ligation at low pH, with a reduction potential of +440 mV, ∼180 mV higher than that of native His/Met cyt b562.
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Aside from FimE, we did not observe mutations in regions unrelated to resistance across mutants of the same resistance group (parallel evolution), suggesting that such mutations had limited, if any, effect on collateral responses in this study.
We had difficulty detecting Smn in homozygous mutant embryos, and the level varied between mutants of the same genotype (Figure 3D).
At 2 4ss, when dbx1 is expressed in a patch of cells in the midbrain (EM subset), ablated mutants of the same stage display apoptosis throughout the neural plate, including the most anterior and lateral regions (compare Fig. 3D and 5D).
Deletion mutants of the same pathway will therefore show the same expression signature.
Two d-mutants of the same motif must not differ by more than 2 d differences.
These lemons are very likely two somatic mutants of the same ancestor.
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