Sentence examples for mutant of human from inspiring English sources
A natural mutant of human lysozyme, D67H, causes hereditary systemic nonneuropathic amyloidosis, which can be fatal.
In this study, we have engineered a hemeless mutant of human cystathionine β-synthase by deletion of the N-terminal 69 amino acids.
Our recently designed A199S/F227A/S287G/A328 W/Y332G mutant of human BChE has a considerably improved catalytic efficiency against -cocaine and has been proven active in vivo.
We present here the Y124H/Y72D mutant of human acetylcholinesterase; its spontaneous reactivation rate after V-agent inhibition is increased up to 110 fold.
The tertiary structure of the Leu308Val mutant of human 20α-hydroxysteroid dehydrogenase (AKR1C1) in complex with the inhibitor 3,5-dichlorosalicylic acid (DCL) has been determined.
Here the I117A mutant of human MATI was identified as the most active variant for biochemical production of SAM analogues from diverse SAAMs.
Two orthogonal destabilizing domains have been developed based on mutants of human FKBP12 as well as bacterial DHFR and these engineered domains have been used to control protein concentration in a variety of contexts in vitro and in vivo.
The molecular basis of the substrate and inhibitor specificity of factor Xa, the serine proteinase of the prothrombinase complex, was investigated by constructing two mutants of human antithrombin (HAT) in which the reactive site loop of the serpin from the P4 P4′ site was replaced with the corresponding residues of the two factor Xa cleavage sites in prothrombin (HAT/Proth-1 and HAT/Proth-2).
To this end, we have constructed mutants of human tyrosinase in which its seven N-glycosylation sites were deleted.
In another study, it was found that R580L and R580K mutants of human TG2 cause increased cell death in response to serum deprivation [24].
Gene deletion mutants of human malaria parasites, which completely arrest during their development inside hepatocytes, are currently being intensely investigated as potential whole-organism malaria vaccines[10], [20], [21].
