Sentence examples for mutant mouse phenotypes from inspiring English sources

The development of mutant mouse models of candidate risk genes and the examination of mutant mouse phenotypes allow direct associations to be made between these genes, specific pathological processes, and behavioral phenotypes, and hence, shed light on genetic contributions to the pathophysiology of schizophrenia.

To date, investigations of Lrig1 and Lrig3 mutant mouse phenotypes have confirmed that both molecules are important for aspects of development, but have done little to clarify their specific functions [24], [27].

Here, we use a phenome-wide approach to systematically compare drug effects with mutant mouse phenotypes (Fig. 1).

The authors also examined links between the a4 subunit encoded by Atp6v0a4, Foxi1 and pendrin, because of similarities in the respective mutant mouse phenotypes.

We evaluate our results with experimentally validated lists of known drug targets and demonstrate on a genomic scale that a similarity between drug effects and mutant mouse phenotypes can reveal drug targets.

Once mouse model phenotypes and human drug effects are made directly comparable, we use a measure of semantic similarity (Pesquita et al., 2008) to compare drug effect profiles with mutant mouse phenotypes.

The BMP4 mutant mouse phenotype adds further support to the hypothesis of a mesodermal identity for BMP-induced hESCs expressing those genes, as it has severe mesoderm defects but no apparent trophoblast phenotype (Winnier et al., 1995).

We have now performed a detailed analysis of the Dnmt2 mutant mouse phenotype with a specific focus on the haematopoietic system as a paradigm for cellular proliferation and differentiation.

Criteria for inclusion in the different groups: I. Existing evidence of co-regulation of cluster member by the factor, and/or a mutant mouse phenotype that affects differentiation of the cell type.

Additionally, when data at the cellular level are lacking, we sometimes refer to the mutant mice phenotype.

Since homozygous mutant mice showed phenotypes typical of the alopecia syndromes, we next sought to characterize its skin pathology.