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A mutant mouse has given scientists the first direct evidence for a theory explaining a rare form of inheritance.
The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a).
Importantly, this knock-in mutant mouse has many features in common with the human disease, thereby making it an excellent model to further probe disease pathogenesis and investigate therapeutic interventions.
The CLOCK mutant mouse has metabolic syndrome [ 16].
Like this mutant, the p66Shc mutant mouse has increased stress resistance without obvious deleterious effects [ 36].
This is because, to the best of our knowledge, no conditional mutant mouse has yet been developed that would permit selective blocking of maternal thyroid function while preserving that of the fetus.
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34 The cells from the Abca12 mutant mouse have severely impaired lipid efflux and intracellular accumulation of neutral lipids.
Explant of Brn3c containing retina in Brn3b −/− mutant mice has remarkable recovery in the neurite outgrowth, demonstrating its growth promoting function.
Generation of Dyrk1A mutant mice has been described previously [19].
The generation and genotyping of RIIβ−/− mutant mice has been described previously [7].
The onset of puberty in other circadian mutant mice has not been described, though an isolated report suggests a slight delay in puberty in Bmal1 knockout mice [21].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com