Sentence examples for mutant mouse embryonic from inspiring English sources

During the next 3 years, Lexicon will put high-throughput robots to work generating 500,000 mutant mouse embryonic stem-cell clones.

One group reported that the Psn-processed N-cadherin ICD targets CBP for degradation, and that Psn FAD-linked mutant mouse embryonic fibroblasts showed increased levels of CBP protein [14].

[38], who, by using mutant mouse embryonic stem cells completely lacking in DNA methylation, have recently shown that chromatin compaction, as assayed by nuclease digestion and sucrose gradient sedimentation, is not affected in these cells, their results underlining the complexity of the relationship between DNA methylation and chromatin structure.

WrnΔ hel /Δ hel mutant mouse embryonic fibroblasts exhibit increased oxidative stress.

BRCA2 or BRCA1 homozygous mutant mouse embryonic fibroblasts (MEFs) from embryos reveal spontaneous chromosomal anomalies and chromosome breakage, which is consistent with a recombination defect [ 20, 37].

Ku70-null and Bax mutant mouse embryonic fibroblasts (MEFs) were used to determine whether cell death susceptibility could be attenuated by Bax deficiency.

In Mks1-mutant mouse embryonic fibroblasts and kidney epithelia, centrosomes are formed but ciliogenesis is severely disrupted.

This elevated basal phosphorylation resulted in a dramatically increased ligand-independent anti-apoptotic signaling and migration, as well as a ligand-dependent increase in proliferation of D849N-mutant mouse embryonic fibroblasts.

Since we observed a strongly increased ligand-independent migration in D849N-mutant mouse embryonic fibroblasts [ 15], we tested if stromal cells of the mutant mouse would invade matrigel plugs more efficiently than those from wild type mouse.

On the other hand, it seems unlikely that an enhanced direct interaction between stromal fibroblasts and tumor cells could account for the earlier tumor establishment in D849N-mutant mice, since there was no difference in proliferation of B16 melanoma cells co-cultured with either irradiated wild type or irradiated D849N-mutant mouse embryonic fibroblasts in vitro (data not shown).

The following has been added to the main text of the manuscript: "To examine the relevance of G-actin to the endogenous PPP1R15 complex, wild type Ppp1r15a+/+ and mutant Ppp1r15amut/mut mouse embryonic fibroblasts (MEFs) These findings are consistent with a role for G-actin in promoting association between endogenous PPP1R15A and PP1".